DOMPurify through 3.3.3 fails to sanitize DOM elements passed via IN_PLACE mode when the element originates from a different window/realm (e.g., an iframe's contentDocument). A cross-realm instanceof check in the private _isNode() function returns false for foreign-realm nodes, causing DOMPurify to stringify the element (yielding '[object HTMLDivElement]'), silently reset IN_PLACE to false, and return the unsanitized element unchanged with any XSS payloads intact.
CWE-754